Pipeline

Advancing Precision Oncology

Apertor is advancing a diverse pipeline of bisteric Interceptors to selectively disrupt protein-protein interactions (PPIs) driving cancer progression by improving depth of response and/or target rebound.  Our lead program disrupts mTORC1/4E-BP1 in solid tumors, with additional discovery programs addressing high-value, therapeutically refractory targets in our pipeline. By leveraging our innovative platform, we will develop transformative therapies that provide effective treatment options for patients.

For inquiries about our science, pipeline, or potential collaborations, please contact us.

TARGET
Indication
Asset
Discovery
IND-Enabling
PHASE 1
mTORC1/4E-BP1
Non-Small Cell
Lung Cancer
(LUAD & LUSC)
AP-457
AP-476 (back-up)
CRAF
KRAS Mutant Cancers
AP-515 Series
Undisclosed Target
Breast Cancer
AP-525 Series